|
rs9933544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analyses revealed that rs2033214 was only significantly associated with low-grade gliomas; rs9933544 and rs13332653 were only significantly associated with glioblastoma multiforme; and rs11860248 was significantly associated with both low-grade gliomas and glioblastoma multiforme, compared with the common wild-type homozygous genotype.
|
25127414 |
2014 |
|
rs9642393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we analyzed tSNPs under different inheritance models, we found rs9642393 in EGFR increased odds of developing GBM in the dominant model.
|
24005813 |
2013 |
|
rs8957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense variant, rs8957 (E[GAG]233D[GAU], SLC2A4RG, 20q13.33), was found being associated with GBM risk, with an odd ratio (OR) of 1.43 (95% confidence interval (CI) = 1.25-1.64, <i>P</i> = 1.72E-07).
|
28979815 |
2017 |
|
rs891835
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified LIG4 rs7325927 and BTBD2 rs11670188 as predictors of STS in GBM and CCDC26 rs10464870 and rs891835, HMGA2 rs1563834, and RTEL1 rs2297440 as predictors of LTS.
|
20368557 |
2010 |
|
rs891835
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009.
|
24870769 |
2014 |
|
rs879254044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this report, we present the case of a 5-year-old female with GBM and CMMRD due to an <i>MSH6</i> homozygous c.1883G>A mutation, who continues to experience an exceptional and durable response (9 months) to the immune checkpoint inhibitor (ICPI) nivolumab.
|
30104292 |
2018 |
|
rs878854066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a protective role in the development of glioblastoma.
|
23860773 |
2013 |
|
rs865880036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
rs863225401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this report, we present the case of a 5-year-old female with GBM and CMMRD due to an <i>MSH6</i> homozygous c.1883G>A mutation, who continues to experience an exceptional and durable response (9 months) to the immune checkpoint inhibitor (ICPI) nivolumab.
|
30104292 |
2018 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotypic and allelic frequencies of seven common polymorphisms in DNA repair genes involved in nucleotide excision repair (ERCC1 rs11615, ERCC2 rs13181, ERCC6 rs4253079), base excision repair (APEX1 rs1130409, XRCC1 rs25487), double-strand break repair (XRCC3 rs861539) and mismatch repair (MLH1 rs1800734) pathways were analyzed in 115 glioblastoma patients and 200 healthy controls.
|
24325908 |
2014 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined XRCC3 Thr241Met polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
22370935 |
2012 |
|
rs861539
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ(2) = 6.558; p = 0.0053).
|
26511493 |
2016 |
|
rs833061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs8057643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In group 2, only one of the 16 SNPs, rs8057643 (located on 16p13.2), was significantly associated with glioblastoma age at diagnosis (nominal P = 0.0017; Bonferroni corrected P = 0.054).
|
17200355 |
2007 |
|
rs78378222
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
|
rs78378222
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The association between rs78378222 and risk was seen for both glioblastoma multiforme (GBM) and non-GBM tumours.
|
23571737 |
2013 |
|
rs78378222
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
rs781490101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, the Nuclear factor of activated T-cells (NFAT)-luciferase reporter was more potently activated by p53-K120R than by wild-type p53 and other mutants in glioblastoma, hepatoma and esophageal carcinoma cells.
|
19416725 |
2009 |
|
rs779221554
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs77724903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sequencing of exon 13 identified mutation c.2372A>T in codon 791 (Y791F) in heterozygous state in one of 100 GBM patients, in two of 65 patients with gastric cancer, in two of 54 PDAC patients and in none of the controls.
|
21311890 |
2011 |
|
rs774238794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1<sup>R132H</sup>) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor.
|
31151327 |
2019 |
|
rs7732320
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
SSBP2 variants are associated with survival in glioblastoma patients.
|
22472174 |
2012 |
|
rs771563543
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mean CBF1 expression is significantly increased in isocitrate dehydrogenase 1 (IDH1) R132H mutant glioblastoma and serves as prognostic marker for prolonged overall survival in brain tumours, particularly after therapy with temozolomide.
|
28571041 |
2017 |
|
rs770462360
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs769809364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that zinc re-established chemosensitivity in breast cancer SKBR3 (expressing R175H mutation) and glioblastoma U373MG (expressing R273H mutation) cell lines.
|
21508668 |
2011 |